THE TIN MAN GUIDE TO STIFF-PERSON SYNDROME
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GABA-ρ Agonists

1. GABOB, Gamibetal, Buxamin


Gamma-Amino-beta-hydroxybutyric acid (GABOB) is a derivative of the neurotransmitter GABA. It is found naturally in the human body but it is not known whether it has an important physiological role at normal concentrations. GABOB has anticonvulsant properties, but is of relatively low potency when used by itself and is more useful as an adjuvant treatment used alongside another anticonvulsant drug. It has two stereoisomers, with the (3S) isomer d-GABOB being around twice as potent an anticonvulsant as the (3R) isomer l-GABOB.


Other studies have suggested it may produce improved learning and memory function, probably through a cholinergic mechanism, as well as boosting growth hormone release. However its effectiveness for these purposes has not been well established and it is not widely used in medicine, although it is sold as a dietary supplement. Drugs.com


2. Progabide, Gabrene


Progabide is an analog and prodrug of gamma-aminobutyric acid used in the treatment of epilepsy. It has agonistic activity at the GABA-α, GABA, and GABAρ receptors. Progabide is approved in France for either monotherapy or adjunctive use in the treatment of epilepsy—specifically, generalized tonic-clonic, myoclonic, partial, and Lennox-Gastaut syndrome seizures in both children and adults. It has been investigated for Parkinson's disease, schizophrenia, clinical depression, anxiety disorder, and spasticity with various levels of success. Wikipedia.



Treatment options  GABAergic drugs   GABA A Agonists   GABA Modulators   GABA B Agonists   GABA P Agonists


GABA Transaminase   GABA RUI   GABA Analogues   GABA Supplement   Muscle Relaxers   Corticosteroids


Antiseizure   Opiate Analgesics   Experimental   IVIG   Plasmapheresis   Immunotherapy   Stem Cell Therapy  PT