www.thetinman.org Copyright © All rights reserved.
Disclaimer: The material presented in this site is intended for public educational purposes only. The author is not offering medical or legal advice. Accuracy of information is attempted but not guaranteed. Before undertaking any diet, or health improvement program, you should consult your physician. The author is in no way liable or responsible for any bodily harm, physical, mental or emotional state of any patient reacting to any of the content on this site. Thetinman.org has not examined, reviewed or tested any product or service mentioned herein. We are not being paid to advertise or promote any product or service mentioned herein. The links are offered strictly as examples of resources available. The site assumes no responsibility or liability of any kind related to the content of external sites or the usage of any product or service referenced. Links to external sites were live at the time of creation of the link. Thetinman.org does not create content for or manage external sites. The information can be changed or removed by the external site’s administrators at any time and they are responsible for the veracity of their information. Links are provided to support our data and supply additional resources. Please report broken links to administrator@thetinman.org. Thetinman.org is not a charitable foundation. It neither accepts nor distributes donations or funds of any kind.
GABA-ρ Agonists
1. GABOB, Gamibetal, Buxamin
Gamma-Amino-beta-hydroxybutyric acid (GABOB) is a derivative of the neurotransmitter GABA. It is found naturally in the human body but it is not known whether it has an important physiological role at normal concentrations. GABOB has anticonvulsant properties, but is of relatively low potency when used by itself and is more useful as an adjuvant treatment used alongside another anticonvulsant drug. It has two stereoisomers, with the (3S) isomer d-GABOB being around twice as potent an anticonvulsant as the (3R) isomer l-GABOB.
Other studies have suggested it may produce improved learning and memory function, probably through a cholinergic mechanism, as well as boosting growth hormone release. However its effectiveness for these purposes has not been well established and it is not widely used in medicine, although it is sold as a dietary supplement. Drugs.com
2. Progabide, Gabrene
Progabide is an analog and prodrug of gamma-aminobutyric acid used in the treatment of epilepsy. It has agonistic activity at the GABA-α, GABA-β, and GABAρ receptors. Progabide is approved in France for either monotherapy or adjunctive use in the treatment of epilepsy—specifically, generalized tonic-clonic, myoclonic, partial, and Lennox-Gastaut syndrome seizures in both children and adults. It has been investigated for Parkinson's disease, schizophrenia, clinical depression, anxiety disorder, and spasticity with various levels of success. Wikipedia.